A timely topic Ram, particularly since I suspect there is a general lack of awareness on the contribution of inflamm-aging to senescence. As with any 'new' therapeutic opportunity, there has been some progress in a few areas, however, apart from say diet and exercise, I think drug trials are still in early stages despite some successes. Another challenge is the multifactorial nature of this beast - right from choosing appropriate molecular targets to figuring our primary and seconday enpoints for regulatory studies for approval, there is lot of work to be done so to speak. One hopes there will be continued support for basic research in this area for it is likely to be exploratory more towards generating hypothesis that can be tested in future be it specific/targeted diet or lifestyle factors or even therapeutic interventions.
Check out Table 2 for past trials...and there are a few in clinicaltrials.gov as well if you search for inflammaging although they don't seem to have a whole lot of drug trials.
A timely topic Ram, particularly since I suspect there is a general lack of awareness on the contribution of inflamm-aging to senescence. As with any 'new' therapeutic opportunity, there has been some progress in a few areas, however, apart from say diet and exercise, I think drug trials are still in early stages despite some successes. Another challenge is the multifactorial nature of this beast - right from choosing appropriate molecular targets to figuring our primary and seconday enpoints for regulatory studies for approval, there is lot of work to be done so to speak. One hopes there will be continued support for basic research in this area for it is likely to be exploratory more towards generating hypothesis that can be tested in future be it specific/targeted diet or lifestyle factors or even therapeutic interventions.
Are there any ongoing therapeutic trials right now?
https://academic.oup.com/cardiovascres/advance-article/doi/10.1093/cvr/cvae240/7895712
Check out Table 2 for past trials...and there are a few in clinicaltrials.gov as well if you search for inflammaging although they don't seem to have a whole lot of drug trials.